β Scribed by Wassarman, Paul M.
No coin nor oath required. For personal study only.
Fertilization in mammalian and nonmammalian organisms has many features in common. These features include a final maturation phase for sperm and eggs, species-specific binding of sperm to eggs, penetration by sperm of one or more extracellular coats surrounding eggs, fusion of sperm and eggs, and activation of eggs. Implicit in this are a variety of basic molecular events, including receptor-ligand interactions, signalling cascades, specific proteolysis, and nuclear transformations. Here, several of these events are addressed for fertilization in animals as diverse as starfish and mice. Dev.
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ONB PLATE (TWEtVE FIQU&ES) 'Part of this work was done at the Station Biologique in %scoff and at the Stazione Zoologica in Naples. The work at the latter station was done during tenure of a National Research Council fellowship by the senior author. The senior author is indebted to director Ch. Pere