Fenoprofen ®calcium in rheumatoid arthritis. a controlled double-blind crossover evaluation

✍ Scribed by Dr. James F. Fries; Melvin C. Britton

• Publisher: John Wiley and Sons
• Year: 1973
• Tongue: English
• Weight: 358 KB
• Volume: 16
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780160507

✦ Synopsis

Abstract

Fenoprofen Calcium (Lilly, Compound 69323) is a new nonsteroidal analgesic and antiinflammatory drug proposed for the treatment of rheumatoid arthritis and allied conditions. In a controlled double‐blind crossover study comparing 6 weeks of Fenoprofen therapy with 6 weeks of treatment with high‐dose acetylsalicylic acid, the aspirin proved minimally more effective and substantially more toxic. Nine of 27 patients found Fenoprofen equal to aspirin, and 6 preferred it. Twelve patients preferred aspirin. The safety of the drug suggested by animal studies appears to be confirmed by these short‐term studies in relatively small numbers of patients. It appears likely that Fenoprofen will provide a useful, although not dramatic, additional agent with which to manage the patient with rheumatoid arthritis.