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Femtogram on-column detection of nicotine by isotope dilution gas chromatography/negative ion detection mass spectrometry

✍ Scribed by Donald A. Cooper; James M. Moore

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
451 KB
Volume
22
Category
Article
ISSN
1076-5174

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✦ Synopsis

A gas chromatographic method, utilizing detection by negative chemical ionization (NCI) mass spectrometry, is presented for the detection of nicotine. The method incorporates derivatization with heptafluorobutyric anhydridelpyridine to yield the ring-opened addition product, 1-[ 4-(3'-pyridyl>4-heptafluorobutyryloxybutyl1-1metbylheptafluorobutanamide. The resulting heptafluorobutanamide is both relatively stable and an excellent electron scavenger. This methodology provides for the detection of nicotine at femtogram on-column levels, the measurement of nicotine over three orders of magnitude, and the minimization of contamination due to environmental nicotine.

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## Abstract A sensitive and specific method for the quantitative determination of paroxetine in human plasma is presented. After solvent extraction from plasma with hexane/ethyl acetate (1 : 1) at alkaline pH and derivatization to the pentafluorobenzyl carbamate derivative, paroxetine was measured