Fe–Mn alloys for metallic biodegradable stents: Degradation and cell viability studies

✍ Scribed by Hendra Hermawan; Agung Purnama; Dominique Dube; Jacques Couet; Diego Mantovani

• Book ID: 103999764
• Publisher: Elsevier Science
• Year: 2010
• Tongue: English
• Weight: 1016 KB
• Volume: 6
• Category: Article
• ISSN: 1742-7061
• DOI: 10.1016/j.actbio.2009.11.025

✦ Synopsis

Biodegradable stents have shown their potential to be a valid alternative for the treatment of coronary artery occlusion. This new class of stents requires materials having excellent mechanical properties and controllable degradation behaviour without inducing toxicological problems. The properties of the currently considered gold standard material for stents, stainless steel 316L, were approached by new Fe-Mn alloys. The degradation characteristics of these Fe-Mn alloys were investigated including in vitro cell viability. A specific test bench was used to investigate the degradation in flow conditions simulating those of coronary artery. A water-soluble tetrazolium test method was used to study the effect of the alloy's degradation product to the viability of fibroblast cells. These tests have revealed the corrosion mechanism of the alloys. The degradation products consist of metal hydroxides and calcium/phosphorus layers. The alloys have shown low inhibition to fibroblast cells' metabolic activities. It is concluded that they demonstrate their potential to be developed as degradable metallic biomaterials.