Felbamate in Experimental Model of Status Epilepticus
β Scribed by Andrey M. Mazarati; Roger A. Baldwin; R. Duane Sofia; Claude G. Wasterain
- Book ID
- 109107106
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2000
- Tongue
- English
- Weight
- 749 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0013-9580
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The efficacy of valproic acid (VPA) in control of generalized convulsive status epilepticus was tested in a rat model. Rats with cortical cobalt lesions were injected with homocysteine thiolactone to induce secondarily generalized tonic-clonic seizures (GTCS). The median effective dose (ED50) for co
The newly introduced antiepileptic drug, lamotrigine, has been reported to have a mechanism of action similar to that of phenytoin. Because phenytoin is a standard clinical treatment for convulsive status epilepticus, we compared the efficacy of lamotrigine to that of phenytoin in a model of seconda