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Feingold syndrome: Report of a new family and review

✍ Scribed by Courtens, W.; Levi, S.; Verbelen, F.; Verloes, A.; Vamos, E.

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 41 KB
Volume: 73
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(19971128)73:1<55::aid-ajmg11>3.0.co;2-q

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✦ Synopsis

Feingold syndrome (or oculodigitoesophagoduodenal syndrome; Microcephaly, Mesobrachyphalangy, Tracheo-esophageal fistula syndrome) is a dominantly inherited combination of hand and foot abnormalities, microcephaly, esophageal/duodenal atresia, short palpebral fissures and learning disabilities, first reported in 1975 (MIM 164280).

We report on the seventh family with Feingold syndrome. The propositus is a male infant with esophageal and duodenal atresia, brachymesophalangy of the fifth fingers, bilateral syndactyly of toes 4-5 (and 2-3), relative microcephaly, and facial anomalies. His mother also has microcephaly, similar facial appearance, short fifth fingers with single flexion crease, syndactyly of toes 4-5, and learning disabilities. The maternal sister, brother, and grandmother of the propositus have the same phenotype.

The 7 families with Feingold syndrome are reviewed. Intestinal (esophageal/ duodenal) atresia/obstruction occurs in approximately 1 ⁄3 of the patients with Feingold syndrome. Am.

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