Feeding S-adenosyl--methionine attenuates both ethanol-induced depletion of mitochondrial glutathione and mitochondrial dysfunction in periportal and perivenous rat hepatocytes*1

Feeding S-adenosyl-l-methionine attenuat

Feeding S-adenosyl-l-methionine attenuates both ethanol-induced depletion of mitochondrial glutathione and mitochondrial dysfunction in periportal and perivenous rat hepatocytes

✍ Carmen García-Ruiz; Albert Morales; Anna Colell; Antonio Ballesta; Joan Rodés; N 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 931 KB

Mitochondrial glutathione plays an important role in maintaining a functionally competent organelle. Previous studies have shown that ethanol feeding selectively depletes the mitochondrial glutathione pool, more predominantly in mitochondria from perivenous hepatocytes. Because S-adenosyl-L-methioni