✦ LIBER ✦
Feedback-mediated neuronal competition for survival cues regulates innervation of a target tissue
✍ Scribed by Yang Li; Marc Fivaz
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 114 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0265-9247
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✦ Synopsis
Abstract
Proper wiring of the nervous system requires tight control of the number of nerve terminals that innervate a target tissue. Recent work by Deppmann et al.,1 now suggests that this is achieved by feedback‐mediated neuronal competition for target‐derived survival cues. The authors' model is inspired by the theory for pattern formation based on self‐activation and lateral inhibition, proposed by Meinhardt and Gierer more than 30 years ago.2 BioEssays 30:929–933, 2008. © 2008 Wiley Periodicals, Inc.