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Feasibility study of imaging a living murine tumor by electron paramagnetic resonance

✍ Scribed by Lawrence J. Berliner; Hirotada Fujii; Xiaoming Wan; S. J. Lukiewicz

Publisher: John Wiley and Sons
Year: 1987
Tongue: English
Weight: 292 KB
Volume: 4
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.1910040410

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✦ Synopsis

An electron paramagnetic resonance image was measured for the first time from in vivo field gradient spectra of a living murine tumor (Cloudman S-91 melanoma in the tail of a DBA-2J mouse) using the paramagnetic nitroxide imaging agent 3-carboxamido-2,2,5,5-tetramethylpyrroline-1-oxyl injected into the tail vein. The experiments were accomplished at L-band frequency (1.55 GHz) with a single-turn flat-loop coil. A cross-sectional image was obtained perpendicular to the tail axis, which clearly distinguished features to the submillimeter resolution level.

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