Feasibility and efficacy of locally delivered enoxaparin via the channeled balloon catheter on smooth muscle cell proliferation following balloon injury in rabbits
✍ Scribed by Hong, Mun K. ;Wong, S. Chiu ;Barry, James J. ;Bramwell, Orville ;Tjurmin, Alexey ;Leon, Martin B.
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 44 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0098-6569
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✦ Synopsis
To determine the potential utility of local treatment of enoxaparin on restenosis, four groups of rabbits underwent balloon injury of bilateral iliac arteries with the Channeled Balloony (balloon/artery 5 1.1), followed by assigned treatment (5 controls received local saline, 7 local-treatment rabbits received a one-time local delivery of 10 mg/kg of enoxaparin, 5 systemic-treatment rabbits received 10 mg/kg of enoxaparin subcutaneously once daily for 1 wk, and 5 combined-treatment rabbits received both local and systemic enoxaparin). The percentage of nuclei positive for proliferating cell nuclear antigen/mm 2 of media 1 wk later was 1.97 6 2.01 for the control group, 2.68 6 2.52 for the local group, 0.22 6 0.32 for the systemic group, and 0.07 6 0.09 for the combined group (P F 0.0001 by Kruskal-Wallis test, with P F 0.05 for combined treatment group vs. controls or local treatment group and systemic vs. local groups). Feasibility study with 3 H-enoxaparin showed intramural retention of 0.1-0.2% of locally delivered amount for 24 h. We conclude that one-time local delivery of enoxaparin following angioplasty is ineffective in inhibiting medial smooth muscle cell proliferation, most likely due to low efficiency. Only sustained treatment resulted in significant reduction.