Fe2+ ions and reduced glutathione — chemical activators of psoralen-sensitized photohaemolysis
✍ Scribed by A.Ya. Potapenko; S.M. Saparov; M.A. Agamalieva; E.P. Lysenko; L.N. Bezdetnaya; V.L. Sukhorukov
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 766 KB
- Volume
- 17
- Category
- Article
- ISSN
- 1011-1344
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✦ Synopsis
The influence of Fe2+ ions and reduced glutathione (GSH) on the haemolysis of erythrocytes photosensitized (366 nm) by psoralen (PUVA haemolysis) was investigated. PUVA haemolysis was induced by the low fluence rate (24 W m-2) and high fluence (greater than 150 W m-2) of UV-A irradiation. It has been shown that Fe2+ ions and GSH activated PUVA haemolysis at both fluence rates of irradiation. PUVA haemolysis activation by Fe2+ ions was more pronounced than that by GSH. It is supposed that activation caused by Fe2+ ions and GSH is connected with their ability to reduce lipid peroxides or psoralen peroxides with the subsequent formation of free radicals. The regeneration of endogenous Fe2+ by reduced glutathione is also possible.