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FC1 lignanolides as potent inhibitors of HIV-1 integrase, a new target for drug development

✍ Scribed by Eich, E.; Pertz, H.; Kaloga, M.; Schulz, J.; Fesen, M.R.; Mazumder, A.; Pommier, Y.


Book ID
122697490
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
139 KB
Volume
2
Category
Article
ISSN
0928-0987

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HIV-1 integrase (IN), one of the essential enzymes in HIV infection, has been validated as a target for HIV treatment. While more than 20 drugs have been approved by the FDA to treat HIV/AIDS, only one drug, Raltegravir (1), was approved as an IN inhibitor. The rapid mutation of the virus, which lea