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FBXW7 and NOTCH1 mutations in childhood T cell acute lymphoblastic leukaemia and T cell non-Hodgkin lymphoma

✍ Scribed by Myoung-Ja Park; Tomohiko Taki; Megumi Oda; Tomoyuki Watanabe; Keiko Yumura-Yagi; Ryoji Kobayashi; Nobuhiro Suzuki; Junichi Hara; Keizo Horibe; Yasuhide Hayashi

Book ID: 108676213
Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 130 KB
Volume: 145
Category: Article
ISSN: 0007-1048
DOI: 10.1111/j.1365-2141.2009.07607.x

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## Background. For T-malignancies in children a poor prognosis is reported. In these malignancies a combination of lymphoma and leukemia is commonly seen at presentation and most patients are treated according to protocols for acute lymphoblastic leukemia (ALL). These protocols are often designed