Favorable early response of secondary chronic myeloid leukemia to imatinib
โ Scribed by Dalia Waldman; Michael Weintraub; Arnold Freeman; Yoram Neumann; Gideon Rechavi; Amos Toren
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 62 KB
- Volume
- 75
- Category
- Article
- ISSN
- 0361-8609
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract ## BACKGROUND: The European LeukemiaNet recommendations for chronic myeloid leukemia (CML) defined a group of patients with suboptimal response to imatinib. The significance of this response was not well defined. ## METHODS: The significance of having had a suboptimal response during
## Abstract The mammalian target of rapamycin (mTOR) is one target of BCRโABL fusion gene of chronic myeloid leukemia (CML). Moreover, it drives a compensatory route to Imatinib mesylate (IM) possibly involved in the progression of leukemic progenitors towards a drugโresistant phenotype. Accordingl
## Abstract ## BACKGROUND. Interferonโalpha (IFNโฮฑ) confers a survival advantage for the minority of patients with chronic myeloid leukemia (CML) who achieve a complete cytogenetic response. The question of whether IFNโฮฑโresponsive patients can experience further improvements with imatinib has not