Fatty acids and production of tylosin-like compounds in Streptomyces fradiae

✍ Scribed by Aleš Vančura; Tomáš Řezanka; Jaroslav Maršálek; Vladimir Křišťan; Gabriela Basařová

• Publisher: John Wiley and Sons
• Year: 1987
• Tongue: English
• Weight: 384 KB
• Volume: 27
• Category: Article
• ISSN: 0233-111X
• DOI: 10.1002/jobm.3620270312

✦ Synopsis

The composition of fatty acids and the spectrum of macrolide antibiotics produced in 7 mutant strains of Streptomyces fradiae, a tylosin producer, were investigated. The strains under investigation differed in the production level and representation of individual tylosin-like compounds. The composition of fatty acids in the mycelium did not depend on the total production. However, the strains producing relomycin in addition to tylosin produced a significantly higher fraction of fatty acids with a higher melting point, and, on the contrary, the strains producing only tylosin or tylosin and desmycosin synthesized a significantly lower proportion of these acids. The results obtained indicate that in addition to the activity and substrate specificity of secondary metabolism enzymes, the composition of the tylosin-like compounds produced can be influenced by the cell membrane and its function.