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Fatty Acid Derivatives of Clozapine: Prolonged Antidopaminergic Activity of Docosahexaenoylclozapine in the Rat

✍ Scribed by Ross J Baldessarini; Alexander Campbell; Nigel L Webb; Charles S Swindell; James G Flood; Victor E Shashoua; Nora S Kula; S Hemamalini; Matthews O Bradley

Book ID
114280705
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
452 KB
Volume
24
Category
Article
ISSN
1470-634X

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Rats were treated once with doses of haloperidol or of droperidol below and above the acute ID50 vs the dopamine agonist apomorphine; they were later challenged with an acute dose of apomorphine (0.3 mg/kg, SC) and rated for stereotyped behavioral responses. The two neuroleptics were similar in acut