Fatigue and daytime somnolence in Machado Joseph Disease (spinocerebellar ataxia type 3)
β Scribed by Joseph H. Friedman; Melissa M. Amick
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 275 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0885-3185
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## Abstract We reported previously that behavior suggestive of rapid eye movement sleep behavior disorder (RBD) was markedly increased in a small population of SCAβ3 patients. We, therefore, asked patients and nonpatient attendees at an SCAβ3 annual clinic to complete a questionnaire soliciting RBD
Rapid eye movement behavior disorder (RBD) is a recently recognized sleep disorder in which patients are occasionally not paralyzed during the dream portions of sleep. When not idiopathic, this state has been associated primarily with parkinsonian conditions but also with a small number of medicatio
An expanded and unstable CAG repeat in the coding region of the MJD1 gene is the mutation responsible for spinocerebellar ataxia 3/Machado-Joseph disease. In order to determine whether there was a higher degree of instability in affected regions, the size of the expanded CAG repeat was analyzed in d