The purpose of this study was to investigate the mechanism of cell death in chondrocytes of the growth plate. In the degenerative chondrocyte zone of the growth plate, apoptotic chondrocytes were defeated by the in situ nick end labelling method, by DNA analysis in agarose gel, and by electron micro
โฆ LIBER โฆ
Fate of the hypertrophic chondrocyte: Microenvironmental perspectives on apoptosis and survival in the epiphyseal growth plate
โ Scribed by Irving M. Shapiro; Christopher S. Adams; Theresa Freeman; Vickram Srinivas
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 456 KB
- Volume
- 75
- Category
- Article
- ISSN
- 1542-975X
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Insulin-like growth factor-II (IGF-II) is an autocrine modulator of epiphyseal chondrogenesis in the fetus. The cellular availability of IGFs are influenced by the IGF-binding proteins (IGFBPs). In this study, we investigated the control of expression and release of IGFBPs from isolated epiphyseal g