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Fate of the 8,9-Z isomer of avermectin B1a in rats

✍ Scribed by Maynard, Michael S.; Gruber, Virgina F.; Feely, William F.; Alvaro, Raul; Wislocki, Peter G.

Book ID
126939701
Publisher
American Chemical Society
Year
1989
Tongue
English
Weight
621 KB
Volume
37
Category
Article
ISSN
0021-8561

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Absfracfi Avemectin B la A44,4a ,2, has been obtained from avenneztin B la. 1, and its bioactivity evaluated. The key step of the transfommtion is the reduction of an intemxdiate allylic radical with aBu@nH. The avermectins are disaccharide derivatives of a structurally similar group of pentacyclic