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Fatal Mycobacterium bovis BCG Infection in TNF-LT-α-Deficient Mice

✍ Scribed by Muazzam Jacobs; Najmeeyah Brown; Nasiema Allie; Bernhard Ryffel


Book ID
115593721
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
425 KB
Volume
94
Category
Article
ISSN
1090-2341

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Signaling via TNF receptor type 1 (TNFR1) was shown to be crucial in host defense against the intracellular pathogens L. monocytogenes, M. tuberculosis and M. bovis. To investigate the function of TNF and LT § in host defense against M. bovis, mice double deficient for TNF and LT § (TNF/LT § -/-), T