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Fatal Hepatic Failure in a Child Treated with Phenytoin and Valproic Acid

✍ Scribed by B. Höjer; A. Rane


Book ID
115264375
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
297 KB
Volume
24
Category
Article
ISSN
0012-1622

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Abnormal metabolism of valproic acid in
✍ W. Kochen; A. Schneider; A. Ritz 📂 Article 📅 1983 🏛 Springer 🌐 English ⚖ 633 KB

A 7-year-old boy developed a severe unilateral grand real seizure at the age of 5 years (phenobarbitone therapy); 1.5 years later valproate (2-propylpentanoic acid, VPA) was added to the therapy. After a seizure-free period of 3 months the patient died from hepatic failure resembling Reye syndrome.