✦ LIBER ✦

Fatal graft versus host disease after platelet transfusions in a child with purine nucleoside phosphorylase deficiency

✍ Scribed by S. Strobel; G. Morgan; A. H. Simmonds; R. J. Levinsky

Publisher: Springer
Year: 1989
Tongue: English
Weight: 325 KB
Volume: 148
Category: Article
ISSN: 0340-6997
DOI: 10.1007/bf00444121

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✦ Synopsis

Fatal graft versus host disease (GVHD) developed in a child with purine nucleoside phosphorylase (PNP) deficiency following an unirradiated platelet transfusion. IV treatment with an anti-T-cell monoclonal antibody (CD7) led to a transient improvement of his GVHD (Grade IV) but did not prevent the fatal outcome. This report emphasizes the need for blood products to be irradiated when cell mediated immunodeficiency is suspected, even in patients with residual immunocompetence.