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FAST2 expression and putative role in activation of primary adult cardiac fibroblasts

✍ Scribed by Julie C. Roth; Jianming Hao; Baiqiu Wang; Liliana Attisano; Ian M.C. Dixon

Book ID
117141356
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
141 KB
Volume
33
Category
Article
ISSN
0022-2828

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## Abstract Fibronectin (FN), a key component of the extracellular matrix, is upregulated in cardiac tissue during myocardial hypertrophy and failure. Here we show that interleukin (IL)‐18, a proinflammatory and pro‐hypertrophic cytokine, stimulates FN expression in adult human cardiac fibroblasts