Fast methods of enantiopurity determination for the Soai reaction: Towards a general enantioenrichment detector?

✍ Scribed by Christopher J. Welch; Mirlinda Biba; Peter Sajonz

• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 226 KB
• Volume: 19
• Category: Article
• ISSN: 0899-0042
• DOI: 10.1002/chir.20336

✦ Synopsis

Abstract

The Soai reaction system possesses a remarkable combination of characteristics (enantioselective autocatalysis, strong positive nonlinearity leading to asymmetric amplification, ability to be triggered by wide variety of exogenous enantioenriched materials) that make it a potential starting point for a generalized detector for enantioenrichment. In this study we apply standard approaches used in pharmaceutical process research to the problem of developing a rapid method for analysis of the enantiopurity of the Soai reaction product. Several methods for rapid analysis (<1 min per sample) are described, including an approach using chiral supercritical fluid chromatography (SFC) and an approach using achiral chromatography with circular dichroism (CD) detection. Some thoughts on incorporation into a device for generalized enantioenrichment detection are presented. Chirality, 2006. © 2006 Wiley‐Liss, Inc.