Fast, low-temperature preparation of carrier-free 17-123I-heptadecanoic acid applied for liver and heart scintigraphy

✍ Scribed by J. Mertens; W. Vanryckeghem; A. Bossuyt

• Book ID: 104683859
• Publisher: Springer
• Year: 1986
• Tongue: English
• Weight: 224 KB
• Volume: 11
• Category: Article
• ISSN: 0340-6997
• DOI: 10.1007/bf00253302

✦ Synopsis

A high-yield method for labelling 17-I-heptadecanoic acid with 123I is described, and a clinical evaluation of the radiopharmaceutical is given. The labelling procedure is based on the use of a conventional ultrasonic bath. It was found that the addition of thiosulphate to the reaction medium avoids the formation of labelled side products and increases the yield considerably. The carrier-free 17-123I-heptadecanoic acid (2 mCi) in 6% human serum albumin was injected IV for heart and liver studies on selected patients with cirrhosis (alcoholic, post-necrotic) and diabetes.