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“Fast isoamylases” in the parotid saliva of children with cystic fibrosis and heterozygous carriers

✍ Scribed by K. M. Doering; C. Arglebe; H. Lubahn; R. Chilla

Publisher
Springer
Year
1977
Tongue
English
Weight
286 KB
Volume
126
Category
Article
ISSN
0340-6997

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✦ Synopsis

On electrophoresis, parotid saliva always exhibits a basic pattern of 6 isoamylases. Additional faster migrating isoamylases occur in varying numbers. These "fast isoamylases" are generated, at least in part, by deamidation. Compared with juvenile and adult controls, a significantly greater number of "fast isoamylases" was found in the parotid saliva of children with cystic fibrosis and their healthy heterozygous parents. A shift in the equilibrium between amidation and deamidation is discussed in terms of its possible connection with the metabolic defect responsible for cystic fibrosis.

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