Fast CEC-MS using poly(dimethylsiloxane) microinjector, short packed column, and low-sheath-flow interface
✍ Scribed by Chao-Jung Chen; Che-Wei Wang; Guor-Rong Her
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 229 KB
- Volume
- 34
- Category
- Article
- ISSN
- 1615-9306
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✦ Synopsis
Abstract
A fast CEC‐MS approach based on a microinjector and a short CEC column was developed. Poly(dimethylsiloxane) was used as the substrate for microinjector fabrication. A short capillary column (∼5 cm) packed with 5 μm octadecyl silica particles was inserted into the microinjector. The microinjector CEC device was interfaced to ESI‐MS using a low‐flow sheath liquid interface. The device delivers the advantages of sample introduction, pre‐concentration, elution, and fast analysis as in chip‐CEC yet avoids the difficulty of packing stationary material into the chip. The online pre‐concentration and CEC‐MS analysis capabilities of this device were demonstrated by analysis of a six‐triazine mixture. A signal enhancement of 20–99‐fold was achieved with a sample loading time of 180 s.