✦ LIBER ✦
Fast capillary GC using a low thermal mass column oven for the determination of residual solvents in pharmaceuticals
✍ Scribed by Frank David; Roman Szücs; Jay Makwana; Pat Sandra
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 633 KB
- Volume
- 29
- Category
- Article
- ISSN
- 1615-9306
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✦ Synopsis
Fast capillary GC using a low thermal mass column oven for the determination of residual solvents in pharmaceuticals
A low thermal mass column oven was used for fast capillary GC analysis (high throughput) of residual solvents in pharmaceutical products. A dedicated capillary column, 20 m L6180 lm ID61 lm DB-624 was programmed from 358C (30 s) to 1508C at 1008C/min and to 2508C (30 s) at 2008C/min, resulting in a total GC cycle time of less than 4 min. Complete separation of a target 20-component mixture was achieved, while method performance in terms of repeatability, sensitivity, and linearity was maintained in comparison to the generic method currently applied in our laboratories.