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Fast and simple procedure for liquid–liquid extraction of 136 analytes from different drug classes for development of a liquid chromatographic-tandem mass spectrometric quantification method in human blood plasma

✍ Scribed by Daniela Remane; Markus R. Meyer; Frank T. Peters; Dirk K. Wissenbach; Hans H. Maurer


Publisher
Springer
Year
2010
Tongue
English
Weight
184 KB
Volume
397
Category
Article
ISSN
1618-2650

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## Abstract A simple, sensitive and rapid liquid chromatographic/electrospray ionization tandem mass spectrometric method was developed and validated for the quantification of lacidipine in human plasma using its structural analogue, amlodipine, as internal standard (IS). The method involves a simp