Fast and optimized T1 mapping technique for the noninvasive quantification of gastric secretion

✍ Scribed by Reto Treier; Andreas Steingoetter; Oliver Goetze; Mark Fox; Michael Fried; Werner Schwizer; Peter Boesiger

• Book ID: 102907109
• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 593 KB
• Volume: 28
• Category: Article
• ISSN: 1053-1807
• DOI: 10.1002/jmri.21400

✦ Synopsis

Abstract

Purpose

To evaluate the noninvasive quantification of gastric secretion volume after administration of a labeled viscous glucose solution by fast T~1~ mapping.

Materials and Methods

T~1~ values of a series of labeled and diluted glucose solutions were measured in vitro to characterize the interrelationship between T~1~ and contrast agent concentration (C~Gd~) as well as the dependency of relaxivity and reference T~1~ (T~10~) on the macromolecular concentration. Abdominal T~1~ mapping in five healthy volunteers of different body mass index was performed after filling an intragastric balloon with a labeled and diluted glucose solution. In additional ex vivo experiments, T~1~ values of gastric (GJ) and duodenal juice (DJ) and 0.1 N HCl solution were determined.

Results

A linear relationship between relaxivity and macromolecular concentration and between T~10~ and macromolecular concentration was found. The in vitro T~1~–C~Gd~ calibration curve was successfully validated in all volunteers. T~1~ values of GJ, DJ, and HCl (2939 msec vs. 2858 msec vs. 2760 msec) were close to the T~1~ of water (≈3000 msec).

Conclusion

The presented method allows one to noninvasively quantify the spatial distribution of gastric secretory products in the human stomach and provides a valuable tool for evaluating the efficacy of drugs to stimulate/inhibit gastric secretion. J. Magn. Reson. Imaging 2008;28:96–102. © 2008 Wiley‐Liss, Inc.