Aryl[a]pyrrolo[3,4-c]carbazoles as selec
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Concha Sanchez-Martinez; Chuan Shih; Margaret M. Faul; Guoxin Zhu; Michael Paal;
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Article
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2003
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Elsevier Science
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English
⚖ 195 KB
The synthesis of new analogues of Arcyriaflavin A in which one indole ring is replaced by an aryl or heteroaryl ring is described. These new series of aryl[a]pyrrolo[3,4-c]carbazoles were evaluated as inhibitors of Cyclin D1-CDK4. A potent and selective D1-CDK4 inhibitor, 7a (D1-CDK4 IC 50 =45 nM),