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Fas-mediated liver injury in ob/ob mice is attenuated in the absence of uncoupling protein-2

✍ Scribed by Fulop, Peter; Resnick, Murray; Wands, Jack R.; Baffy, Gyorgy


Book ID
122754902
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
266 KB
Volume
124
Category
Article
ISSN
0016-5085

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Fatty liver is vulnerable to conditions that challenge hepatocellular energy homeostasis. Lipidladen hepatocytes highly express uncoupling protein-2 (UCP2), a mitochondrial carrier that competes with adenosine triphosphate (ATP) synthesis by mediating proton leak. However, evidence for a link betwee