Fas ligand (FasL) kills sensitive Fas receptor (FasR)-bearing cells by inducing apoptosis. FasL expressed by non-lymphoid cells within the eye and the testis mediates immune privilege by inducing apoptosis of Fas-sensitive infiltrating pro-inflammatory immune effector cells. It has previously been d
✦ LIBER ✦
Fas ligand mediates immune privilege and not inflammation in human colon cancer, irrespective of TGF-β expression
✍ Scribed by Houston, A; Bennett, M W; O'Sullivan, G C; Shanahan, F; O'Connell, J
- Book ID
- 109997743
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 304 KB
- Volume
- 89
- Category
- Article
- ISSN
- 0007-0920
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## Abstract Despite the fact that expression of Fas ligand (FasL) in cytotoxic T lymphocytes (CTLs) and in natural killer (NK) cells plays an important role in Fas‐mediated tumor killing, During tumor progression FasL‐expressing tumor cells are involved in __counterattacking__ to kill tumor‐infiltr