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Fas Ligand Is Present in Tumors of the Ewing's Sarcoma Family and Is Cleaved into a Soluble Form by a Metalloproteinase

✍ Scribed by Nicholas Mitsiades; Vassiliki Poulaki; Vassiliki Kotoula; Alvaro Leone; Maria Tsokos


Book ID
117022860
Publisher
American Society for Investigative Pathology
Year
1998
Tongue
English
Weight
937 KB
Volume
153
Category
Article
ISSN
0002-9440

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✍ Jan Michel; Joachim Langstein; Ferdinand Hofstädter; Herbert Schwarz 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 82 KB 👁 2 views

CD137 (ILA/4-1BB) is a member of the tumor necrosis factor receptor family and regulates activation, proliferation and programmed cell death in T lymphocytes. Here we show the existence of a soluble form of CD137 (sCD137) of 16 kDa. sCD137 is released by activated lymphocytes, and in contrast to mem