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Fas activates NF-κB and induces apoptosis in T-cell lines by signaling pathways distinct from those induced by TNF-α

✍ Scribed by Packham, Graham; Lahti, Jill M; Fee, Brian E; Gawn, Jonathan M; Coustan-Smith, Elaine; Campana, Dario; Douglas, Iris; Kidd, Vincent J; Ghosh, Sankar; Cleveland, John L

Book ID
110015637
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
450 KB
Volume
4
Category
Article
ISSN
1350-9047

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## Abstract Resistance to tumor necrosis factor (TNFα)‐induced apoptosis in various cancer cells has been attributed to the activation of the transcription factor NF‐κB. Ebselen (2‐phenyl‐1,2‐benzisoselenazol‐3[2H]one)—a selenoorganic compound is known to prevent TNFα‐mediated NF‐κB activity. As gl