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Farnesyltransferase inhibitors and their potential role in therapy for myelodysplastic syndromes and acute myeloid leukaemia

✍ Scribed by Thorsten Braun; Pierre Fenaux


Book ID
108675714
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
196 KB
Volume
141
Category
Article
ISSN
0007-1048

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A phase 1-2 study of a farnesyltransfera
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## Abstract ## BACKGROUND: The authors conducted a phase 1/2 study of tipifarnib in combination with idarubicin and cytarabine (IA) in 95 patients with previously untreated acute myeloid leukemia (AML) or high‐risk myelodysplastic syndrome. ## METHODS: Induction consisted of idarubicin 12 mg/m^2