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Farnesyltransferase inhibitors and myeloid malignancies: Phase I evidence of Zarnestra activity in high-risk leukemias

✍ Scribed by Jeffrey E Lancet; Joseph D Rosenblatt; Judith E Karp


Book ID
117832592
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
123 KB
Volume
39
Category
Article
ISSN
1532-8686

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A phase 1-2 study of a farnesyltransfera
✍ Elias Jabbour; Hagop Kantarjian; Farhad Ravandi; Guillermo Garcia-Manero; Zeev E πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 221 KB πŸ‘ 1 views

## Abstract ## BACKGROUND: The authors conducted a phase 1/2 study of tipifarnib in combination with idarubicin and cytarabine (IA) in 95 patients with previously untreated acute myeloid leukemia (AML) or high‐risk myelodysplastic syndrome. ## METHODS: Induction consisted of idarubicin 12 mg/m^2