Fanconi anemia (FA) has rarely been reported in black children either in the United States or Africa. This report describes 25 black African children with FA seen in Johannesburg over an ll-year period. The prevalence of homozygotes was estimated to be 1:476,000. Clinical manifestations, mean age at
Fanconi anemia in blacks
β Scribed by Alter, Blanche P.
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 112 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0148-7299
No coin nor oath required. For personal study only.
β¦ Synopsis
Letter to the Editor Fanconi Anemia in Blacks
To the Editor:
The article by Macdougall et al. [19901 on Fanconi anemia (FA) in black African children points out features which suggest that FA in blacks resembles more closely FA in every population group except Afrikaaners. However, they underestimate the frequency with which FA has been reported in blacks. There are at least 9 such references to 14 more cases [
π SIMILAR VOLUMES
## Abstract ## BACKGROUND Fanconi anemia (FA) is an autosomal recessive disease associated with an abnormal response to DNA damage. Although FA is well known for the association of aplastic anemia and characteristic birth defects, leukemia and solid tumors also occur at a high rate in this group o
In Fanconi anemia (FA) cells the duration of the G2 phase of the cell cycle prolonged. Such a slowing of the G2 phase can be induced in normal cells by irradiation with gamma rays during S phase, which also further increases the duration of G2 in FA cells. The addition of caffeine during the last 7