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FAN1variants identified in multiple-case early-onset breast cancer families via exome sequencing: no evidence for association with risk for breast cancer

โœ Scribed by Daniel J. Park; Fabrice A. Odefrey; Fleur Hammet; Graham G. Giles; Laura Baglietto; ABCFS; MCCS; John L. Hopper; Daniel F. Schmidt; Enes Makalic; Olga M. Sinilnikova; David E. Goldgar; Melissa C. Southey


Publisher
Springer US
Year
2011
Tongue
English
Weight
252 KB
Volume
130
Category
Article
ISSN
0167-6806

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Genetic screening of women from multiple-case breast cancer families and other research-based endeavors have identified an extensive collection of germline variations of BRCA1 and BRCA2 that can be classified as deleterious and have clinical relevance. For some variants, such as those in the conserv