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Family with Graves disease, multinodular goiter, nonmedullary thyroid carcinoma, and alveolar rhabdomyosarcoma

✍ Scribed by Druker, Harriet A.; Kasprzak, Lidia; Bégin, Louis R.; Jothy, Serge; Narod, Steven A.; Foulkes, William D.

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 15 KB
Volume: 72
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(19971003)72:1<30::aid-ajmg6>3.0.co;2-z

No coin nor oath required. For personal study only.

✦ Synopsis

Benign thyroid disease is a risk factor for nonmedullary thyroid carcinoma [Houlston and Stratton: Q J Med 88:685-693, 1995]. We report on a family with 7 members with benign and/or malignant thyroid neoplasia; one affected female died of a paravertebral alveolar rhabdomyosarcoma at age 20. The occurrence of thyroid nodular hyperplasia, nonmedullary thyroid cancer, and rhabdomyosarcoma in the same family may be due to chance, common environmental factors, or, most likely, genetic predisposition.

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