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Family history of Crohn's disease is associated with an increased risk for Crohn's disease of the pouch

✍ Scribed by Bo Shen; Feza H. Remzi; Jeffrey P. Hammel; Bret A. Lashner; Charles L. Bevins; Ian C. Lavery; Jan Wehkamp; Victor W. Fazio

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 126 KB
Volume: 15
Category: Article
ISSN: 1078-0998
DOI: 10.1002/ibd.20646

No coin nor oath required. For personal study only.

✦ Synopsis

Background: Crohn's disease (CD) of the pouch can occur in patients with restorative proctocolectomy and ileal pouch-anal anastomosis originally performed for a preoperative diagnosis of ulcerative colitis (UC). CD of the pouch was often observed in patients with a family history of CD. The purpose was to determine whether the family history of CD increased the risk for CD of the pouch in patients who underwent restorative proctocolectomy.

Methods: A total of 558 eligible patients seen in the Pouchitis

Clinic were enrolled, including 116 patients with CD of the pouch and 442 patients with a normal pouch or other pouch disorders. Demographic and clinical variables were included in the study. Multivariable logistic regression analyses were performed.

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