Family history of cancer and risk of pancreatic cancer: A pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan)

✍ Scribed by Eric J. Jacobs; Stephen J. Chanock; Charles S. Fuchs; Andrea LaCroix; Robert R. McWilliams; Emily Steplowski; Rachael Z. Stolzenberg-Solomon; Alan A. Arslan; H. Bas Bueno-de-Mesquita; Myron Gross; Kathy Helzlsouer; Gloria Petersen; Wei Zheng; Ilir Agalliu; Naomi E. Allen; Laufey Amundadottir; Marie-Christine Boutron-Ruault; Julie E. Buring; Federico Canzian; Sandra Clipp; Miren Dorronsoro; J. Michael Gaziano; Edward L. Giovannucci; Susan E. Hankinson; Patricia Hartge; Robert N. Hoover; David J. Hunter; Kevin B. Jacobs; Mazda Jenab; Peter Kraft; Charles Kooperberg; Shannon M. Lynch; Malin Sund; Julie B. Mendelsohn; Tracy Mouw; Christina C. Newton; Kim Overvad; Domenico Palli; Petra H.M. Peeters; Aleksandar Rajkovic; Xiao-Ou Shu; Gilles Thomas; Geoffrey S. Tobias; Dimitrios Trichopoulos; Jarmo Virtamo; Jean Wactawski-Wende; Brian M. Wolpin; Kai Yu; Anne Zeleniuch-Jacquotte

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: French
• Weight: 203 KB
• Volume: 127
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.25148

✦ Synopsis

Abstract

A family history of pancreatic cancer has consistently been associated with increased risk of pancreatic cancer. However, uncertainty remains about the strength of this association. Results from previous studies suggest a family history of select cancers (i.e., ovarian, breast and colorectal) could also be associated, although not as strongly, with increased risk of pancreatic cancer. We examined the association between a family history of 5 types of cancer (pancreas, prostate, ovarian, breast and colorectal) and risk of pancreatic cancer using data from a collaborative nested case‐control study conducted by the Pancreatic Cancer Cohort Consortium. Cases and controls were from cohort studies from the United States, Europe and China, and a case‐control study from the Mayo Clinic. Analyses of family history of pancreatic cancer included 1,183 cases and 1,205 controls. A family history of pancreatic cancer in a parent, sibling or child was associated with increased risk of pancreatic cancer [multivariate‐adjusted odds ratios (ORs) = 1.76, 95% confidence interval (CI) = 1.19–2.61]. A family history of prostate cancer was also associated with increased risk (OR = 1.45, 95% CI = 1.12–1.89). There were no statistically significant associations with a family history of ovarian cancer (OR = 0.82, 95% CI = 0.52–1.31), breast cancer (OR = 1.21, 95% CI = 0.97–1.51) or colorectal cancer (OR = 1.17, 95% CI = 0.93–1.47). Our results confirm a moderate sized association between a family history of pancreatic cancer and risk of pancreatic cancer and also provide evidence for an association with a family history of prostate cancer worth further study.