## Abstract Increased levels of insulinโlike growth factor I (IGFโI) may directly stimulate breast cell proliferation and promote growth and survival of transformed cells. Higher levels of IGFโI have been associated with increased risk of premenopausal breast cancer but not postmenopausal breast ca
Family-based genetic association study of insulin-like growth factor I microsatellite markers and premenopausal breast cancer risk
โ Scribed by Gordon Fehringer; Norman F. Boyd; Julia A. Knight; Andrew D. Paterson; Gillian S. Dite; Graham G. Giles; Melissa C. Southey; Irene L. Andrulis; John L. Hopper; Hilmi Ozcelik
- Book ID
- 106378204
- Publisher
- Springer US
- Year
- 2009
- Tongue
- English
- Weight
- 211 KB
- Volume
- 118
- Category
- Article
- ISSN
- 0167-6806
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## Abstract Biologic evidence suggests substantial effect of insulinโlike growth factor (IGF)โI in mammary cell carcinogenesis. However, controversy remains regarding the association between circulating IGFโI levels and the risk of premenopausal breast cancer in epidemiologic studies. In addition,
## Abstract The physical inactivity and obesity involved in hyperglycemia and hyperinsulinemia is supposed to lead to an increased bioavailability of insulinโlike growth factorโI (IGFโI). The carcinogenic effect of IGFโI may be influenced by IGF binding proteins. We investigated the association bet