Family-based association testing of OCD-associated SNPs of SLC1A1 in an autism sample
โ Scribed by Camille W. Brune; Soo-Jeong Kim; Gregory L. Hanna; Eric Courchesne; Catherine Lord; Bennett L. Leventhal; Edwin H. Cook
- Book ID
- 112007781
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 174 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1939-3792
- DOI
- 10.1002/aur.11
No coin nor oath required. For personal study only.
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## Abstract SLC1A1 encodes a neuronal glutamate transporter and is a promising candidate gene for obsessiveโcompulsive disorder (OCD). Several independent research groups have reported significant associations between OCD and single nucleotide polymorphisms (SNPs) in this gene. Previously, we evalu
## Abstract The TPH1 and TPH2 genes encode the rateโlimiting enzymes that control serotonin biosynthesis, and serotonin is clearly altered in autism. In the current study, eight SNPs in the TPH1 gene region and eight SNPs within the TPH2 gene were examined by familyโbased association tests in a lar