Family-based association study of Neuregulin 1 with psychotic bipolar disorder
β Scribed by Fernando S. Goes; Virginia L. Willour; Peter P. Zandi; Pamela L. Belmonte; Dean F. MacKinnon; Francis M. Mondimore; Barbara Schweizer; Elliot S. Gershon; Francis J. McMahon; James B. Potash
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 270 KB
- Volume
- 150B
- Category
- Article
- ISSN
- 1552-4841
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## Abstract Neurotransmission pathways/systems have been proposed to be involved in the pathophysiology and treatment of bipolar disorder for over 40 years. In order to test the hypothesis that common variants of genes in one or more of five neurotransmission systems confer risk for bipolar disorde
Association analysis of candidate genes may represent a strategy for clarifying the genetic components involved in bipolar disorder. Polymorphism at dopamine receptor genes DRD2, DRD4, and dopamine and serotonin transporter genes (DAT, SERT) has been used in previous association studies. Some author