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Familial thrombocytopenia associated with platelet autoantibodies and chromosome breakage

โœ Scribed by F. M. Helmerhorst; D. C. Heaton; P. E. Crossen; A. E. G. Kr. Borne; C. P. Engelfriet; A. T. Natarajan

Book ID
104705416
Publisher
Springer
Year
1984
Tongue
English
Weight
529 KB
Volume
65
Category
Article
ISSN
0340-6717

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โœฆ Synopsis

An extended family is described in which three members had thrombocytopenia. These affected members had chromosomal changes resembling those found in Fanconi's anaemia, though they lacked the development defects associated with that syndrome. One had bone-marrow hypoplasia and died of squamous cell carcinoma of the mouth at the age of 27. In addition, all three had platelet autoantibodies not found in any other family members tested. There was no linkage between the thrombocytopenia and HLA groups. The nature of the association of thrombocytopenia, platelet autoantibodies and chromosomal abnormalities in this family remains doubtful.

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โœ Ruth E. Luddy; Lorraine A. A. Champion; Allen D. Schwartz ๐Ÿ“‚ Article ๐Ÿ“… 1978 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 661 KB

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