Familial polyposis

✍ Scribed by Jerome J. Decosse; Mark B. Adams; Robert E. Condon

• Book ID: 102664348
• Publisher: John Wiley and Sons
• Year: 1977
• Tongue: English
• Weight: 582 KB
• Volume: 39
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(197701)39:1<267::aid-cncr2820390141>3.0.co;2-x

✦ Synopsis

Familial polyposis is a genetically-transmitted disease characterized by multiple adenomatous colorectal polyps and a high risk for development of adenocarcinoma. Familial polyposis and Gardner's syndrome should be differentiated from other penetically-linked polyposis syndromes lacking a predisposition for cancer. Total colectomy and ileorectal anastomosis, aggressive follow-up and intensive surveillance of non-polyp bearing relatives can reduce the risk of developing cancer. From an epidemiologic point of veiw, polyposis is a valuable model for the study of the interaction of genetic and environmental factors in the genesis of colon cancer.