Familial occurrence of isolated IgA deficiency associated with antibodies to IgA. Evidence against a structural gene defect
✍ Scribed by Erna van Loghem
- Publisher
- John Wiley and Sons
- Year
- 1974
- Tongue
- English
- Weight
- 460 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0014-2980
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✦ Synopsis
Abstract
Two families were investigated for the occurrence of IgA deficiency and antibodies to IgA. Several members of the families were found to be deficient for IgA1, as well as for IgA2, which strongly suggested that the disorder is genetically determined. By means of typing for genetic markers a defect of structural α genes could be excluded.
An autosomal recessive mode of inheritance of genes committed with the synthesis of IgA accounts best for the observations.
Anti‐IgA antibodies of different specificity were encountered in eight out of fifteen IgA‐deficient family members; sometimes more than one specificity was observed in the same individual. There was no association with Gm allotypes, nor any evidence for a possible stimulation of antibody production.