Familial occurrence of colon and uterine carcinoma and of lymphoproliferative malignancies. II. Chromosomal and immunologic abnormalities

✍ Scribed by Ivan P. Law; Ariel C. Hollinshead; Jacqueline Whang-Peng; Jack H. Dean; Robert K. Oldham; Ronald B. Herberman; Marvin C. Rhode

• Publisher: John Wiley and Sons
• Year: 1977
• Tongue: English
• Weight: 623 KB
• Volume: 39
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(197703)39:3<1229::aid-cncr2820390331>3.0.co;2-j

✦ Synopsis

Cytogenic and immunologic studies were performed on 20 members of a family who had an increased susceptibility to carcinomas of the colon, uterus and of lymphoproliferative malignancy. Chromosomal abnormalities such as small G and/or long submetacentric marker chromosome and other aberrations were observed in members who had cancer as well as some asymptomatic siblings. In addition, impairment of T cell function was noted in many of the members suggesting that defective cell-mediated immunity, which also may be genetically determined, played an important role in the expression of this disease.