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Familial genes in sporadic disease: Common variants of α-synuclein gene associate with Parkinson's disease

✍ Scribed by Owen A. Ross; David Gosal; Jeremy T. Stone; Sarah J. Lincoln; Michael G. Heckman; G. Brent Irvine; Janet A. Johnston; J. Mark Gibson; Matthew J. Farrer; Timothy Lynch


Book ID
113776053
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
413 KB
Volume
128
Category
Article
ISSN
0047-6374

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## Abstract α‐Synuclein is one of the main components of Lewy bodies, a pathological marker of Parkinson's disease (PD). Certain missense mutations of the α‐synuclein gene cause familial PD, but the role of the gene in sporadic PD is still controversial. We scrutinized polymorphisms of the α‐synucl